Hirudin (rec-Hirudin)

Description:
Hirudin is the most potent and specific thrombin inhibitor known. It forms a stable equimolar complex with thrombin. The complete structure of hirudin has been elucidated [Dodt et al., 1984] and a gene coding for hirudin was subsequently synthesized and expressed in yeast [Meyhack et al., 1987] and other micro-organisms. The amino acid sequence of recombinant hirudin (r-Hirudin, [Leu1, Thr2]-63-desulfatohirudin) corresponds to natural hirudin except for the substitution of leucine for isoleucine at the N-terminal end of the molecule and the absence of a sulfate group on the tyrosine at position 63.

Application:
r-Hirudin can be utilised for many analytical and preparative purposes in hemostaseological test procedures as well as in blood and plasma fractionation to block the multiple enzymatic and non­enzymatic actions of thrombin. r-Hirudin may be added to test mixtures to exclude undesired thrombin actions due to contaminations of reagents with prothrombin or with prothrombin activators.

Formula: C₂₈₇H₄₄₀N₈₀O₁₁₀S₆

MW: 6979.5

Storage:
May be used by the expiry date given on the label when stored unopened, protected from moisture, in the dark, 2°-8°C. Avoid contamination of the reagents by micro-organisms. Shipment of product does not require cooling during the time of transportation.

Note: r-Hirudin is to be used for in vitro diagnostic purposes only.

Category: Research use only

Type: Inhibitor

Product Availability: Germany, Israel and Egypt

Manufacturer: DSM Nutritional Products Ltd. Branch Pentapharm, Switzerland

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