Pefabloc® TH, Inhibitor for Thrombin/NAPAP

Description:
The benzamidine moiety is a key structure for the development of inhibitors of trypsin-like enzymes. It mimics the protonated side-chain of the basic amino acids Arg and Lys which is hydrolysed by these enzymes. Pefabloc^®TH (NAPAP) is one of the most potent and selective competitive inhibitors of thrombin.

Application:
Pefabloc^®TH can be used in diagnostic systems, analytical applications, research and industrial purification processes to exclude undesired thrombin activity. It can also be used as a potent anticoagulant in in vitro test systems.

Formula: C₂₇H₃₁O₄N₅S · AcOH

MW: 581.7

Chem. name:
Nα-(2-Naphthylsulfonylglycyl)-4-amidino-(D,L)-phenylalanine piperidide acetate (NAPAP)

Solubility: 1.5 mg/ml (2.6 mM) in H₂O

Storage:
May be used by the expiry date given on the label when stored unopened, protected from moisture, in the dark, 2-8°C. Avoid contamination of the reagents by micro-organisms. Shipment of product does not require cooling during the time of transportation.

K_i constants:
K_i values for the inhibition of several trypsin-like serine proteases by Pefabloc^®TH

 
Category: Research use only

Type: Inhibitor

Product Availability: Germany, Israel and Egypt

Manufacturer: DSM Nutritional Products Ltd. Branch Pentapharm, Switzerland

For more information please click .pdf icon below.