1-chain tPA, human, recombinant (frozen)
Description
Tissue Plasminogen Activator (tPA) is a protease of the S1 family (trypsin family) and is found in a wide variety of mammalian tissues, especially endothelial cells. tPA is secreted as a single chain precursor, which is cleaved to a two-chain form by plasmin. Both forms are catalytically active and have similar enzymatic properties in the presence of fibrin.
Preparation
The 1-chain tPA is the secretion product of a Chinese Hamster Ovary cell line that had been transfected with the cDNA for human tPA obtained from a human melanoma cell line.
Molecular Weight
About 70 kDa (as determined on SDS-PAGE).
Purity
>95% 1-chain tPA (70 kD), <5% 2-chain tPA via SDS-PAGE analysis under reducing conditions.
![938242_938011_ADG171_ADG173](/uploads/artikeldetails/938242_938011_adg171_adg173.jpg)
Specific Activity
The specific activity is approximately 580,000 IU/mg.
Presentation
100 µg (ADG173) or 1 mg (ADG171) of sterile filtered single-chain recombinant tPA in a frozen solution of 34 mg/mL (3.4%) L-arginine, 10 mg/mL (1%) phosphoric acid.
Storage
Store frozen at -80°C. It is recommended to avoid freeze-thaw cycles.
Category: Research use only
Type: Protein
Product Availability: Worldwide
Manufacturer: ImmBioMed GmbH & Co KG, Germany
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1-chain tPA, human, recombinant (frozen)
Cat.No. ADG173
Article no.: 938011
Unit: 50 ug
Code: ADG173
Manufacturer: ImmBioMed GmbH & Co. KG