anti-human CD36, Clone TR9

Description
CD36 (fatty acid translocase, FAT) is an 88 kDa ditopic glycosylated protein that belongs to the class B family of scavenger receptors. CD36 is expressed by most resting marginal zone B cells but not by follicular and B1 B cells, and it is rapidly induced on Follicular B cells in vitro upon TLR and CD40 stimulation. CD36 does not affect the development of B cells, but modulates both primary and secondary antibody response. Similarly to glucose transporter GLUT4, CD36 is translocated from intracellular pools to the plasma membrane following cell stimulation by insulin. In mouse, CD36 is responsible for gustatory perception of long chain fatty acids.

Properties
The monoclonal antibody ADG5022/L (clone TR9) is a murine monoclonal antibody, subclass IgG₁. The antibody has been purified from ascites by protein­-A affinity chromatography, Purity > 95% (by SDS­-PAGE).
The antibody reacts with CD36 (GPIIIb), a 85 kDa integral membrane glycoprotein expressed on platelets, macrophages, endothelial cells, early erythroid cells and megakaryocytes. The antibody TR9 crossblocks binding of FITC­-labeled standard antibody OKM5. Anti­-CD36 antibodies inhibit adhesive functions (e.g. adherence of infected erythrocytes to target cells)

Presentation
Vial containing 100 µg /100 µl (ADG5022) or 300 µg/ 300 µl (ADG5022L) of purified antibody in PBS containing 0.09 % sodium azide (pH 7.2). The IgG concentration is 1 mg/ml. Spin the vial briefly before opening.

Storage and Stability
Store at 4 °C. For long­term storage aliquot and store at ­-20°. It is recommended to avoid freeze-thaw cycles. The reagent is stable until the expiry date stated on the vial label.

Applications
Flow Cytometry

Category: Research use only

Type: Antibody

Product Availability: Worldwide

Manufacturer: ImmBioMed GmbH & Co KG, Germany

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