murine MAb against Tumor associated antigen L6 (TM4SF1), clone HD-pKe 104 1.1
Description
Tumor associated antigen L6 (TM4SF1) is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility (2, 3). This encoded protein is a cell surface antigen and is highly expressed in different carcinomas (4-6).
Aliases: transmembrane 4 L six family member 1, transmembrane 4 superfamily member 1, transmembrane 4 L6 family member 1,
surface marker 1
Preparation
The monoclonal antibody ADG0015 (clone HD-pKe 104 1.1) is a murine monoclonal antibody, subclass IgG1 recognizing the human Tumor associated antigen L6. Mice were immunized with recombinant tumor antigen L6. The antibody has been purified from cell culture supernatant using Protein G affinity chromatography.
Presentation
Screw capped vial containing 250 µg of purified antibody in PBS pH 7.4 + 0.01% ProClin300. The IgG concentration is given on the vial label. Spin the vial briefly before opening.
Storage and Stability
Store the antibody at 2°-8°C. For long-term storage the antibody should be aliquoted and stored at –20°C or colder. It is recommended to avoid freeze-thaw cycles.
Applications (1)
• Western-Blot
• Immunopurification
• Immunocytology
Category: Research use only
Type: Antibody
Product Availability: Worldwide
Manufacturer: ImmBioMed GmbH & Co KG, Germany
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murine MAb against Tumor associated antigen L6 (TM4SF1), clone HD-pKe 104 1.1
Cat.No. ADG0015 (research box)
Article no.: 938482
Unit: 250 µg
Code: ADG0015
Manufacturer: ImmBioMed GmbH & Co. KG - from the research box
References
- Molecular and functional characterization of the four-transmembrane molecule L6 in epidermal keratinocytes. Storim J et al., Exp Cell Res. 2001 Jul 15;267(2):233-42.
- TM4SF1: a tetraspanin-like protein necessary for nanopodia formation and endothelial cell migration. Zukauskas A et al. , Angiogenesis. 2011 Sep;14(3):345-54.2.
- The L6 protein TM4SF1 is critical for endothelial cell function and tumor angiogenesis. Shih SC et al., Cancer Res. 2009 Apr 15;69(8):3272-7.
- TM4SF1, a novel primary androgen receptor target gene over-expressed in human prostate cancer and involved in cell migration. Allioli N et al., Prostate. 2011 Aug 1;71(11):1239-50.
- The tumour-associated antigen L6 (L6-Ag) is recruited to the tetraspanin-enriched micro-domains: implication for tumour cell motility. Lekishvili T et al., J Cell Sci. 2008 Mar 1;121(Pt 5):685-94.
- Tumor-associated antigen L6 and the invasion of human lung cancer cells. Kao YR et al., Clin Cancer Res. 2003 Jul;9(7):2807-16.