Synthetic Inhibitor of Fibrin Polymerization

Description
The synthetic inhibitor binds with a high affinity to fibrinogen, inhibits fibrin polymerization, modifies the mechanical properties of fibrin clots and can dissociate non-stabilized fibrin gels.

Chemistry
Formula: H-Gly-Pro-Arg-Pro-OH×AcOH
MW: 485.5
Solubility: readily soluble in water

Application
The inhibitor is added to fibrinogen containing reaction mixtures to inhibit disturbing fibrin-related turbidity, gel formation and fibrin deposition in diagnostic and preparative procedures (e.g. measurement of thrombin generation in plasma). The inhibitor is also used to inhibit fibrin formation during purification and processing of clotting factors and other plasma proteins.

Recommended inhibitor concentrations
Gelation prevention:
des-AB-fibrin: concentration 0.5-2.3 mM
des-A-fibrin: concentration 2.3 mM
human plasma, HC-II test: concentration 0.5 mg/ml
bov. fibrinogen 0.2% / thrombin 0.5 U/ml: concentration 1.5 mg/ml
Clot liquefaction:
des-AB-fibrin: concentration 15.0 mM
des-A-fibrin: concentration 1.0 mM

Presentation
Vial containing 50 mg lyophilized inhibitor.

Reconstitution
Reconstitute with filtered deionized water.

Storage and Stability
May be used by the expiry date given on the label when stored unopened, protected from moisture, in the dark, 2-8°C. Avoid contamination of the reagents by micro-organisms. Shipment of product does not require cooling during the time of transportation.

Category: Research use only

Type: Inhibitor

Product Availability: Worldwide

Manufacturer: ImmBioMed GmbH & Co KG, Germany

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